![]() Increased perioculomotor Urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. ![]() PMC 2785284.įonareva I, Spangler E, Cannella N, Sabino V, Cottone P, Ciccocioppo R, Zorrilla EP, Ryabinin AE. CRF system recruitment mediates dark side of compulsive eating. PMC2785284.Ĭottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf J, Fekete EM, Steardo L, Rice KC, Grigoriadis D, Conti B, Koob GF, Zorrilla EP. CRF-induced amygdala GABA release plays a key role in alcohol dependence. Roberto M Cruz MT Gilpin NW Sabino V Schweitzer P Bajo M Cottone P Madamba S Stouffer DG Zorrilla EP Koob GF Siggins GR Parsons LH. Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake. Repunte-Canonigo V, van der Stap LD, Chen J, Sabino V, Wagner U, Zorrilla EP, Schumann G, Roberts AJ, Sanna PP. Activation of σ-receptor induces binge-like drinking in Sardinian alcohol-preferring rats. Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Systemic urocotrin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. 2012 Jan 219(2):377-86.įekete EM, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale WW, Koob GF, Zorrilla EP. A modified adjusting delay task to assess implusive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT2A/C and 5-HT1A receptor agonists. īlasio A, Narayan AR, Kaminski BJ, Steardo L, Sabino V,, Cottone P. Antagonism of Sigma-1 Receptors Blocks Compulsive-Like Eating. Ĭottone P, Wang X, Park JW, Valenza M, Blasio A, Kwak J, Iyer MR, Steardo L, Rice KC, Hayashi T, Sabino V. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdale. PMID: 24107576īlasio A, Iemolo A, Sabino V, Petrosino S, Steardo L, Rice KC, Orlando P, Arturo Iannotti F, Di Marzo V, Zorrilla EP, Cottone P. Nicotine dependence produces hyperalgesia: role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA). 2014.īaiamonte BA, Valenza M, Roltsch EA, Whitaker AM, Baynes BB, Sabino V, Gilpin NW. Behav Pharmacol “Special Issue on Behavioural Pharmacology of Stress”. Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior. Sabino co-directs a graduate course in neuropsychopharmacology offered for the first time in Fall 2010 which examines the interaction between behavior and classes of drugs that affect the central nervous system giving emphasis on how behavioral studies can assist in our understanding of mental disorders.īlasio A, Rice KC, Sabino V, Cottone P. ![]() The approach of the laboratory is interdisciplinary, involving behavioral neuroscience, neuropharmacology, neuroanatomy, biochemistry and molecular biology.ĭr. Research is also conducted on the neurobiology of stress-related disorders such as anxiety and depression. Animal models for excessive drinking are studied in order to identify compounds for potential clinical development. Sabino is working toward the development of new therapeutic agents to alleviate alcohol addiction. Studies on addiction aim to understand the neurobiological substrates of alcohol abuse and dependence by exploring the role of neurochemical systems in excessive alcohol drinking.ĭr. Sabino is co-director of the Laboratory of Addictive Disorders, and is currently researching the neurobiology of addiction and stress-related disorders. Ph.D.: University of Palermo, Palermo, Italyĭr. Pharmacokinetic and Pharmacodynamic Simulators.Student Handbook / NRSA & Fellowship Guidelines/ Scientific Meetings.Boston University School of Medicine: Pharmacology & Experimental Therapeutics
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